Description

N3-Pegn-Oh 2K, 5K, 10K, 20K is a heterobifunctional polyethylene glycol (PEG) derivative featuring an azide (N3) group at one terminus and a hydroxyl (OH) group at the other. This molecular architecture is critical for creating biocompatible, hydrophilic linkers in advanced bioconjugation and materials science. It is essential for researchers and manufacturers in pharmaceuticals, diagnostics, and nanotechnology who require precise, water-soluble spacers for coupling biomolecules or modifying surfaces. The product is available in discrete molecular weights (2K, 5K, 10K, 20K) to provide flexibility in linker length and hydrodynamic volume for specific application needs.

Application

• Bioconjugation and ADC Development: Serves as a versatile linker for connecting antibodies, proteins, or peptides to drugs, toxins, or fluorophores via click chemistry (azide-alkyne cycloaddition).
• PEGylation of Therapeutics: Used to modify peptides, proteins, and oligonucleotides to enhance solubility, reduce immunogenicity, and prolong circulation half-life in vivo.
• Hydrogel and Biomaterial Synthesis: Acts as a cross-linking agent or functional modifier to create hydrophilic, biocompatible networks for tissue engineering and drug delivery systems.
• Surface Functionalization: Enables the "PEGylation" of nanoparticles, quantum dots, and diagnostic chips to improve stability, reduce non-specific binding, and provide a handle for further chemical attachment.
• Diagnostic Reagent Preparation: Utilized in the development of sensitive assay components, such as enzyme or antibody conjugates, for ELISA and other bioanalytical techniques.
• Polymer Chemistry: Functions as a macroinitiator or monomer in the synthesis of block copolymers with tailored properties for specialized material applications.

Basic Information

Product Name	N3-Pegn-Oh 2K, 5K, 10K, 20K
CAS No.	73342-16-2
Molecular Formula	CnH2n+2On+1N3 (n varies by PEG chain length)
Molecular Weight	~2000, ~5000, ~10000, ~20000 g/mol (nominal)
Synonyms	Azido-PEG-OH; N3-PEG-OH; α-Azido-ω-hydroxy poly(ethylene glycol); PEG-Azide, Hydroxy Terminated; Azido Polyethylene Glycol Monol; Azido-PEGn-alcohol; Heterobifunctional PEG Azide Hydroxyl; mPEG-N3-OH; 2-[2-(2-Azidoethoxy)ethoxy]ethanol (homolog series)
EINECS	Contact for details

Quality Control

Our N3-Pegn-Oh products are manufactured under a quality management system and undergo rigorous analytical testing to ensure batch-to-batch consistency and high purity. Key parameters verified include PEG chain length distribution (by GPC/SEC), functional group integrity (azide content by NMR/IR), and low levels of moisture and impurities. Certificates of Analysis (COA) detailing purity, molecular weight, and endotoxin levels (where applicable) are available upon request to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere (argon or nitrogen), consider to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Molecular Weight (Nominal)	2,000 / 5,000 / 10,000 / 20,000 Da
Purity (HPLC/GPC)	> 95%
Polydispersity Index (PDI)	< 1.05
Azide Content (NMR)	> 90% of theory
Water Content (KF)	< 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.