Description

Macbecin I is a potent ansamycin-class antibiotic compound with significant biological activity. This specialized chemical is valued in research and development for its unique mechanism of action, which involves the inhibition of bacterial RNA polymerase. It serves as a critical reference standard and intermediate for pharmaceutical research, particularly in the study of novel antimicrobial agents and antitumor therapies. Key industries that utilize this compound include pharmaceutical R&D, biotechnology, and academic research institutions focused on infectious diseases and oncology.

Application

• Pharmaceutical Reference Standard: Used as a high-purity analytical standard for quality control and method development in antibiotic research.
• Antimicrobial Research: Serves as a key intermediate or active component in studies targeting drug-resistant bacterial strains.
• Biochemical Pathway Studies: Employed in molecular biology to investigate bacterial transcription and RNA polymerase inhibition mechanisms.
• Antitumor Agent Development: Investigated for its potential application in cancer research due to its ansamycin structure and biological activity.
• Academic and Institutional Research: Utilized in universities and research institutes for fundamental studies in microbiology and pharmacology.

Basic Information

Product Name	Macbecin I
CAS No.	73341-72-7
Molecular Formula	C31H43NO9
Molecular Weight	573.68 g/mol
Synonyms	Macbecin; Macbecin I; Antibiotic C 14919-C; Ansamitocin P-0; Maytansinoid P-0; NSC 330500; (3S,4S,5R,6R,8S,9S,10E,12E,15S,17S)-15-[(2S,3S,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-4,6,8,10,12,17-hexamethyl-3-[(2R)-1-methylprop-1-en-2-yl]oxy-1-oxacyclooctadeca-10,12-diene-2,5,7,9-tetrone
EINECS	Contact for details

Quality Control

Our Macbecin I is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods for structural confirmation. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product at -20°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.