Description

1-Pyrrolidinecarbonyl Chloride, 2,5-Dimethyl-, cis- (9Ci) is a specialized heterocyclic acid chloride derivative, serving as a high-value building block in advanced organic synthesis. Its core value lies in its reactivity as an acylating agent, enabling the efficient introduction of the sterically defined 2,5-dimethylpyrrolidine-1-carbonyl moiety into target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, where precise stereochemistry and functional group manipulation are critical.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where its structural motif can contribute to biological activity and selectivity.
• Peptidomimetic Chemistry: Employed to introduce constrained pyrrolidine scaffolds into peptide analogs, enhancing metabolic stability and binding affinity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Utilized in the synthesis of functional polymers and dendrimers with tailored properties.
• Custom Synthesis and R&D: A critical reagent for contract research organizations (CROs) and academic laboratories engaged in novel heterocyclic chemistry.

Basic Information

Product Name	1-Pyrrolidinecarbonyl Chloride, 2,5-Dimethyl-, cis- (9Ci)
CAS No.	73301-09-4
Molecular Formula	C7H12ClNO
Molecular Weight	161.63 g/mol
Synonyms	cis-2,5-Dimethylpyrrolidine-1-carbonyl chloride; (2R,5S)-2,5-Dimethylpyrrolidine-1-carbonyl chloride; (2S,5R)-2,5-Dimethylpyrrolidine-1-carbonyl chloride; 2,5-Dimethyl-1-pyrrolidinecarbonyl chloride, cis-; NSC 339063
EINECS	Contact for details

Quality Control

Our production of 1-Pyrrolidinecarbonyl Chloride, 2,5-Dimethyl-, cis- (9Ci) adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot is characterized by multiple analytical techniques including NMR, HPLC, and GC to confirm identity, isomeric purity (cis- isomer), and chemical purity. Comprehensive Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and reacts with strong acids/organic solvents; therefore, it must be kept under an inert atmosphere (e.g., nitrogen or argon) and away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isomeric Purity (cis- isomer)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.