Description

Sp-Adenosine 3',5'-Cyclic Monophosphothioate Triethylamine is a chemically modified, non-hydrolyzable analog of cyclic adenosine monophosphate (cAMP) where a sulfur atom replaces an oxygen atom in the phosphate group. This modification makes it a highly potent and selective activator of protein kinase A (PKA), serving as a critical tool for studying intracellular signaling pathways. It is essential for researchers and manufacturers in life sciences, pharmaceutical R&D, and biochemical diagnostics who require reliable, high-purity reagents for signal transduction studies and assay development.

Application

• Biochemical Research: As a cell-permeable, hydrolysis-resistant activator of Protein Kinase A (PKA) for studying cAMP-mediated signaling cascades.
• Pharmaceutical Development: Used in high-throughput screening (HTS) assays to identify and characterize novel modulators of PKA activity for drug discovery.
• Diagnostic Kit Manufacturing: A key component in enzyme-linked immunosorbent assay (ELISA) and other diagnostic kits designed to measure PKA activity or cAMP levels in biological samples.
• Cell Biology Studies: Investigating the role of cAMP in cellular processes such as metabolism, gene expression, and ion channel regulation.
• Neuroscience Research: Exploring synaptic plasticity, neurotransmitter release, and long-term potentiation (LTP) mechanisms where PKA plays a central role.
• Enzyme Kinetics: Serving as a stable substrate or activator in kinetic studies to determine the catalytic properties of PKA and related enzymes.

Basic Information

Product Name	Sp-Adenosine 3',5'-Cyclic Monophosphothioate Triethylamine
CAS No.	73208-40-9
Molecular Formula	C10H12N5O5PS • C6H15N
Molecular Weight	463.42 g/mol (Free acid: 346.26 g/mol)
Synonyms	Sp-cAMPS triethylamine salt; Adenosine 3',5'-cyclic monophosphorothioate, Sp-isomer, triethylammonium salt; (Sp)-Adenosine 3',5'-cyclic monophosphorothioate triethylamine; Sp-cyclic AMPS; cAMP-S, Sp-isomer; Rp/Sp-cAMPS; Protein Kinase A Activator (Sp-isomer); 8-(Thiophosphoryl)adenosine cyclic 3',5'-(hydrogen phosphate) triethylamine salt
EINECS	Contact for details

Quality Control

Our Sp-Adenosine 3',5'-Cyclic Monophosphothioate Triethylamine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the high standards required for sensitive research applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.