Description

2',3',5'-Tri-o-Acetyl-2N,2N-Dimethyl-Guanosine is a key protected nucleoside derivative, specifically a guanosine analog with acetyl and dimethylguanidine protecting groups. This compound is essential for advanced oligonucleotide synthesis, serving as a critical building block for the controlled introduction of modified guanine bases. It is primarily required by research institutions and pharmaceutical companies engaged in the development of antisense oligonucleotides, siRNA, and other therapeutic nucleic acids. The product, CAS NO 73196-87-9, offers high purity and consistency, which are fundamental for ensuring the fidelity and reproducibility of complex synthetic sequences.

Application

• Pharmaceutical Intermediate: A vital precursor in the synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Oligonucleotide Synthesis: Serves as a protected phosphoramidite monomer for solid-phase synthesis of DNA/RNA analogs in research and therapeutic development.
• Biochemical Research: Used in studies investigating RNA structure, function, and protein-nucleic acid interactions where modified bases are required.
• Antisense & siRNA Therapeutics: A key raw material for manufacturing oligonucleotides designed for gene silencing and targeted therapeutic applications.
• Diagnostic Probe Development: Employed in creating labeled nucleic acid probes for sensitive detection and diagnostic assays.
• Process Development & Scale-up: Supports process chemistry and scale-up activities for GMP-grade active pharmaceutical ingredient (API) manufacturing.

Basic Information

Product Name	2',3',5'-Tri-o-Acetyl-2N,2N-Dimethyl-Guanosine
CAS No.	73196-87-9
Molecular Formula	C₁₉H₂₆N₆O₈
Molecular Weight	466.45 g/mol
Synonyms	N2,N2-Dimethyl-2',3',5'-tri-O-acetylguanosine; 2',3',5'-Tri-O-acetyl-N2,N2-dimethylguanosine; Guanosine, 2',3',5'-triacetate, N2,N2-dimethyl-; N2,N2-Dimethylguanosine 2',3',5'-triacetate; 2-(Dimethylamino)-9-[(2R,3R,4R,5R)-3,4-diacetyloxy-5-(acetyloxymethyl)oxolan-2-yl]-1,9-dihydro-6H-purin-6-one; Protected Guanosine Derivative; DMG-triacetate
EINECS	Contact for details

Quality Control

Our 2',3',5'-Tri-o-Acetyl-2N,2N-Dimethyl-Guanosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific project or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.