Description

2'-Deoxy-8-(9H-Fluoren-2-Ylamino)-Guanosine is a modified nucleoside analog, specifically a guanosine derivative with a fluorenylamino substituent at the 8-position. This compound is of significant value as a key intermediate and building block in the synthesis of oligonucleotides and nucleotide analogs for advanced research applications. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in the development of novel therapeutics, diagnostic probes, and molecular biology tools.

Application

• Oligonucleotide Synthesis: A critical phosphoramidite precursor for the solid-phase synthesis of modified DNA and RNA strands.
• Antiviral & Anticancer Drug Development: Serves as a core scaffold for creating nucleoside analog prodrugs targeting viral polymerases and cellular replication pathways.
• Molecular Probe Design: Used to incorporate fluorescent or bulky tags into oligonucleotides for studies on nucleic acid structure, function, and protein interactions.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog to investigate the mechanisms of DNA repair and replication enzymes.
• Apitamer Development: Facilitates the introduction of specific modifications to enhance the stability and binding affinity of nucleic acid aptamers.
• High-Purity Reference Standard: Provides a characterized standard for quality control and analytical method development in pharmaceutical manufacturing.

Basic Information

Product Name	2'-Deoxy-8-(9H-Fluoren-2-Ylamino)-Guanosine
CAS No.	73051-69-1
Molecular Formula	C23H20N6O4
Molecular Weight	444.44 g/mol
Synonyms	8-(2-Fluorenylamino)-2'-deoxyguanosine; 2'-Deoxy-8-(2-fluorenylamino)guanosine; 8-(9H-Fluoren-2-ylamino)-2'-deoxyguanosine; 8-(2-Fluorenylamino)-2'-deoxy-Guanosine; dG(8-Fl); 8-Fluoren-2-ylamino-2'-deoxyguanosine; 2'-Deoxy-8-(9H-fluoren-2-ylamino)guanosine; Guanosine, 2'-deoxy-8-[(9H-fluoren-2-yl)amino]-
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-8-(9H-Fluoren-2-Ylamino)-Guanosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the product should be handled in a dry environment and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.