Description

5-Acetyl-2-Methylbenzenesulfonyl Chloride is a specialized aromatic sulfonyl chloride derivative that serves as a critical building block in advanced organic synthesis. Its core value lies in its dual reactive sites, the sulfonyl chloride and acetyl groups, which enable precise chemical modifications for creating complex molecular architectures. This high-purity intermediate is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active compounds and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly sulfonamide-based therapeutics with potential antibacterial, diuretic, or anticancer activity.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and plant growth regulators that require specific sulfonyl moiety incorporation.
• Dye and Pigment Manufacturing: Acts as a reactive intermediate for producing sulfonated azo dyes and high-performance pigments with enhanced solubility and color fastness.
• Polymer Chemistry: Serves as a monomer or cross-linking agent in the production of specialty polymers, including sulfonated polyelectrolytes for membrane and resin applications.
• Chemical Research & Development: A versatile reagent for constructing complex heterocycles and for introducing the sulfonyl functional group in medicinal chemistry and material science projects.
• Ligand and Catalyst Preparation: Useful for synthesizing specialized ligands for metal catalysis or for modifying surface properties of catalytic materials.

Basic Information

Product Name	5-Acetyl-2-Methylbenzenesulfonyl Chloride
CAS No.	73035-17-3
Molecular Formula	C9H9ClO3S
Molecular Weight	232.68 g/mol
Synonyms	1-(4-Methyl-3-sulfonylchloridophenyl)ethanone; 2-Methyl-5-acetylbenzenesulfonyl chloride; 4-Acetyl-2-methylbenzenesulfonyl chloride; 5-Acetyl-o-toluenesulfonyl chloride; 3-Acetyl-6-methylbenzenesulfonyl chloride; 2-Methyl-5-acetylphenylsulfonyl chloride; 1-[3-(Chlorosulfonyl)-4-methylphenyl]ethan-1-one
EINECS	Contact for details

Quality Control

Our 5-Acetyl-2-Methylbenzenesulfonyl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, to meet exacting customer specifications. Certificates of Analysis (COA) documenting identity, purity, and related substances are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.