Description

5(8H)-Naphthacenone, 8-Acetyl-10-(3-Amino-2,3,6-Trideoxy-.Alpha.-L-Lyxo-Hexopyranosyl)Oxy-7,9,10,12-Tetrahydro-6,8,11-Trihydroxy-12-Imino-1-Methoxy-, (8S,10S)- is a complex, high-purity anthracycline derivative with significant biological activity. This compound is critical for advanced pharmaceutical research and development, particularly in the field of oncology. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of novel chemotherapeutic agents and the study of DNA-interactive molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel anthracycline-based anticancer drugs and antibiotics.
• Biochemical Research: Used as a reference standard and active compound in studies targeting topoisomerase II inhibition and DNA intercalation mechanisms.
• Antitumor Agent Development: Serves as a core structural moiety for developing new chemotherapeutic entities with modified efficacy and toxicity profiles.
• Academic & Institutional Research: Employed in university and contract research organization (CRO) labs for investigating structure-activity relationships (SAR) of complex glycosylated polyketides.
• Process Chemistry: Used in scale-up and optimization studies for the production of specialized active pharmaceutical ingredients (APIs).

Basic Information

Item	Detail
Product Name	5(8H)-Naphthacenone, 8-Acetyl-10-(3-Amino-2,3,6-Trideoxy-.Alpha.-L-Lyxo-Hexopyranosyl)Oxy-7,9,10,12-Tetrahydro-6,8,11-Trihydroxy-12-Imino-1-Methoxy-, (8S,10S)-
CAS No.	72983-78-9
Molecular Formula	C26H30N2O11
Molecular Weight	546.52 g/mol
Synonyms	8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-12-imino-1-methoxy-5(8H)-naphthacenone; (8S,10S)-Isomer of aclacinomycin T; Aclacinomycin T derivative; Anthracycline glycoside intermediate; 12-Imino derivative of aclacinomycin
EINECS	Contact for details

Quality Control

Our 5(8H)-Naphthacenone derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.