Description

2-Pyrrolidinecarbonylchloride,1-Acetyl-,(S)-(9Ci) is a high-purity chiral building block and key synthetic intermediate. Its value lies in its role as a versatile reagent for introducing the (S)-1-acetyl-2-pyrrolidinecarbonyl moiety, a structural motif of significant interest in medicinal chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the development of active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of protease inhibitors, neurological agents, and other biologically active compounds.
• Peptidomimetic Research: Used in the design and construction of peptide analogs and peptidomimetics to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Serves as a key starting material or coupling agent in stereoselective synthesis to create enantiomerically pure products.
• API Development: Employed in the research, development, and scale-up of new Active Pharmaceutical Ingredients (APIs).
• Fine Chemical Production: Utilized in custom synthesis and the manufacture of specialty chemicals requiring high chiral purity.
• Academic & R&D: A valuable reagent for chemical research in academic institutions and corporate R&D laboratories exploring new synthetic methodologies.

Basic Information

Product Name	2-Pyrrolidinecarbonylchloride,1-Acetyl-,(S)-(9Ci)
CAS No.	72983-26-7
Molecular Formula	C7H10ClNO2
Molecular Weight	175.61 g/mol
Synonyms	(S)-1-Acetyl-2-pyrrolidinecarbonyl chloride; (S)-N-Acetylprolyl chloride; (S)-1-Acetylpyrrolidine-2-carbonyl chloride; L-N-Acetylprolyl chloride; (2S)-1-Acetyl-2-pyrrolidinecarbonyl chloride; 1-Acetyl-L-prolyl chloride; (S)-1-Acetylproline chloride; Proline, N-acetyl-, chloride, L-
EINECS	Contact for details

Quality Control

Our 2-Pyrrolidinecarbonylchloride,1-Acetyl-,(S)-(9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing key parameters such as assay, enantiomeric excess, and impurity profiles. Our quality system is designed to meet the stringent requirements of GMP and ISO standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.