Description

Adenylyl-Imidodiphosphate, Tetralithium Salt is a high-purity, non-hydrolyzable ATP analog widely used as a potent inhibitor of ATP-dependent enzymes. This compound is critical for biochemical research and diagnostic applications where stable nucleotide binding is required without the risk of hydrolysis. It is an essential reagent for researchers and manufacturers in pharmaceutical development, enzymology studies, and molecular biology diagnostics.

Application

• Enzyme Inhibition Studies: Used as a non-hydrolyzable ATP analog to study the mechanisms of ATPases, kinases, and other ATP-binding proteins.
• Biochemical Research: Serves as a critical tool in mechanistic enzymology to trap enzyme-substrate complexes and elucidate catalytic cycles.
• Diagnostic Kit Manufacturing: Employed in the formulation of assay kits for research and clinical diagnostics that target ATP-dependent pathways.
• Pharmaceutical Screening: Utilized in high-throughput screening (HTS) assays to identify potential inhibitors of ATP-utilizing enzymes relevant to disease.
• Structural Biology: Aids in X-ray crystallography and NMR studies by providing a stable, co-crystallizable ligand for protein structure determination.
• Signal Transduction Research: Applied in studies of G-proteins and other GTP/ATP-binding proteins to investigate regulatory mechanisms.

Basic Information

Product Name	Adenylyl-Imidodiphosphate, Tetralithium Salt
CAS No.	72957-42-7
Molecular Formula	C10H12Li4N6O12P3 • xH2O
Molecular Weight	Contact for details
Synonyms	AMP-PNP, Tetralithium Salt; Adenylyl Imidodiphosphate, Li4 Salt; Adenosine 5'-(β,γ-Imido)triphosphate, Tetralithium Salt; ATPγN, Tetralithium Salt; γ-Imido-ATP, Tetralithium Salt; Non-hydrolyzable ATP analog, Li4 Salt; 5'-Adenylyl (β,γ-imido)diphosphonate, Tetralithium Salt
EINECS	Contact for details

Quality Control

Our Adenylyl-Imidodiphosphate, Tetralithium Salt is manufactured under controlled conditions to ensure high batch-to-batch consistency suitable for sensitive research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/UV)	Conforms
Purity (HPLC)	≥ 95%
Assay (UV Spectrophotometry)	≥ 90% (anhydrous basis)
Water Content (KF)	Contact for details
Solubility	Soluble in water, buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.