Description

4-Bromothiophene-3-carbonyl chloride is a versatile and highly reactive organobromine building block, crucial for introducing the 4-bromothiophene moiety into complex molecular architectures. Its primary value lies in its acyl chloride functionality, which facilitates efficient amide bond formation and other nucleophilic substitution reactions under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for the synthesis of active pharmaceutical ingredients (APIs), functional polymers, and liquid crystal materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing thiophene-based drug candidates, including kinase inhibitors and antiviral agents.
• Agrochemical Synthesis: Used in the production of novel herbicides and fungicides that incorporate the bromothiophene scaffold for enhanced bioactivity.
• Material Science: Serves as a monomer or precursor for conductive polymers, organic semiconductors, and liquid crystals (OLEDs).
• Chemical Research: Employed in academic and industrial R&D for exploring new heterocyclic compounds and catalytic processes.
• Peptide Mimetics: The acyl chloride group is used to create thiophene-containing peptide analogs and bio-conjugates.
• Coordination Chemistry: Acts as a ligand precursor for metal-organic frameworks (MOFs) and catalysts.

Basic Information

Item	Details
Product Name	4-Bromothiophene-3-carbonyl Chloride
CAS No.	72899-51-5
Molecular Formula	C5H2BrClOS
Molecular Weight	225.49 g/mol
Synonyms	3-Bromo-4-chlorocarbonylthiophene; 4-Bromo-3-thiophenecarbonyl chloride; 4-Bromothiophene-3-carboxylic acid chloride; 3-Thiophenecarbonyl chloride, 4-bromo-; 4-Bromo-3-thenoyl chloride
EINECS	Contact for details

Quality Control

Every batch of 4-Bromothiophene-3-carbonyl Chloride is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed and allowed to reach room temperature before opening to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and alcohols.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline solid or liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (Titration)	95.0 - 102.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.