Description

Neplanocin B is a potent adenosine analog and carbocyclic nucleoside derivative with significant biological activity. This compound is a key intermediate and reference standard in antiviral and anticancer research, valued for its mechanism of action as an S-adenosylhomocysteine hydrolase (SAHase) inhibitor. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in developing novel therapeutics.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in the synthesis of novel antiviral and anticancer agents.
• Biochemical Studies: Used as a potent inhibitor of S-adenosylhomocysteine hydrolase (SAHase) to study methylation processes, viral replication mechanisms, and cellular signaling pathways.
• Antiviral Agent Development: Investigated for its activity against a range of viruses, including orthopoxviruses (e.g., vaccinia) and other DNA viruses, due to its ability to disrupt viral mRNA cap methylation.
• Oncology Research: Explored for its potential cytotoxic effects and role in inducing apoptosis in various cancer cell lines, making it a compound of interest in preclinical cancer research.
• Enzyme Inhibition Assays: Employed as a specific tool compound in high-throughput screening (HTS) and enzymatic assays to identify and characterize new SAHase inhibitors.
• Process Chemistry & Scale-Up: Used as a building block and benchmark in process optimization and the scale-up synthesis of more complex nucleoside analogs.

Basic Information

Product Name	Neplanocin B
CAS No.	72877-49-7
Molecular Formula	C11H13N5O3
Molecular Weight	263.25 g/mol
Synonyms	(–)-Neplanocin B; 9-[(1R,2S,3R)-2,3-Dihydroxy-4-(hydroxymethyl)cyclopent-4-en-1-yl]adenine; 9-[(1R,2S,3R)-2,3-Dihydroxy-4-(hydroxymethyl)-4-cyclopenten-1-yl]adenine; 4'-Homoneplanocin A; Carbocyclic 3-deazaadenosine analog; SAH Hydrolase Inhibitor; NSC 377364
EINECS	Contact for details

Quality Control

Every batch of Neplanocin B is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed HPLC purity data, to ensure the compound meets the stringent requirements for research and development applications. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.