Description

Neplanocin D is a synthetic carbocyclic nucleoside analog, a structural derivative of adenosine, known for its potent biological activity. This compound is a critical intermediate and research tool in the development of novel antiviral and anticancer therapeutics. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies focused on nucleoside chemistry and drug discovery. The product is supplied as a high-purity reference standard and building block for advanced synthesis.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate in the synthesis of more complex nucleoside analogs with potential antiviral and antitumor properties.
• Antiviral Agent Studies: Investigated for its activity as an S-adenosylhomocysteine hydrolase (SAHase) inhibitor, a mechanism relevant to disrupting viral replication.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to understand cellular methylation processes and nucleoside metabolism.
• Oncology Research: Explored for its potential cytotoxic effects and role in inducing apoptosis in various cancer cell lines.
• Chemical Synthesis: Acts as a sophisticated chiral building block for the preparation of novel carbocyclic compounds and modified nucleosides.
• Reference Standard: Provides a high-purity analytical standard for quality control, method development, and identification in pharmaceutical analysis.

Basic Information

Product Name	Neplanocin D
CAS No.	72877-47-5
Molecular Formula	C11H13N5O3
Molecular Weight	263.25 g/mol
Synonyms	(1'R,2'S,3'R)-9-[2',3'-Dihydroxy-4'-(hydroxymethyl)cyclopent-1'-yl]adenine; (-)-Neplanocin D; Carbocyclic 3-deazaadenosine; 3-Deazaneplanocin A precursor; 9-[(1'R,2'S,3'R)-2',3'-Dihydroxy-4'-(hydroxymethyl)cyclopentyl]adenine; c3-DeazaAdo; NSC 614373
EINECS	Contact for details

Quality Control

Our Neplanocin D is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent product degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.