Description

1H-Imidazole-1-Carbonyl Chloride, 2,3-Dihydro-2-Oxo- (9Ci) is a reactive heterocyclic acid chloride derivative, serving as a crucial building block in advanced organic synthesis. Its value lies in its ability to introduce the imidazolidine-2,4-dione (hydantoin) scaffold, a privileged structure in medicinal chemistry, under controlled conditions. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active compounds.

Application

• Pharmaceutical Intermediate: Key synthon for the synthesis of hydantoin and thiohydantoin derivatives, which are core structures in numerous bioactive molecules.
• Active Pharmaceutical Ingredient (API) Development: Used in constructing potential drug candidates targeting neurological disorders, anticonvulsants, and antiarrhythmic agents.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and plant growth regulators with enhanced efficacy.
• Peptidomimetics & Bioconjugation: Facilitates the introduction of cyclic urea moieties into peptides and proteins for drug discovery and biochemical probes.
• Material Science Research: Employed in the synthesis of specialty polymers and functional materials with tailored properties.
• Custom Synthesis & Contract Manufacturing: A critical reagent for fine chemical and CDMO (Contract Development and Manufacturing Organization) services.

Basic Information

Product Name	1H-Imidazole-1-Carbonyl Chloride, 2,3-Dihydro-2-Oxo- (9Ci)
CAS No.	72699-62-8
Molecular Formula	C4H3ClN2O2
Molecular Weight	146.53 g/mol
Synonyms	1H-Imidazole-1-carbonyl chloride, 2,3-dihydro-2-oxo-; 2,4-Imidazolidinedione-1-carbonyl chloride; Hydantoin-1-carbonyl chloride; 1-Carbamoylimidazolidine-2,4-dione chloride; 1-Chlorocarbonylimidazolidine-2,4-dione; N-Carbamoylhydantoin acid chloride; (2,5-Dioxoimidazolidin-1-yl)carbonyl chloride
EINECS	Contact for details

Quality Control

Our production of 1H-Imidazole-1-Carbonyl Chloride, 2,3-Dihydro-2-Oxo- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is fully characterized and undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.