Description

3,5-Dibromo-2-Chlorosalicylanilide-4'-Isothiocyanate is a specialized halogenated salicylanilide derivative with a reactive isothiocyanate functional group. This compound is a crucial high-purity intermediate for the synthesis of advanced chemical probes, diagnostic reagents, and targeted bioactive molecules. It is primarily required by research institutions and manufacturers in the pharmaceutical, biotechnology, and life science sectors for developing covalent inhibitors, affinity labels, and fluorescence-based detection systems.

Application

• Bioconjugation & Probe Synthesis: Key intermediate for creating covalent labeling probes, affinity tags, and fluorescence-conjugated reagents for protein and cellular studies.
• Pharmaceutical Research: Used in the development of targeted covalent inhibitors and novel drug candidates that require specific, irreversible binding to biological targets.
• Diagnostic Reagent Manufacturing: Serves as a building block for enzyme-linked immunosorbent assay (ELISA) components, lateral flow assay conjugates, and other immunodiagnostic chemicals.
• Chemical Biology Tool Development: Employed to synthesize activity-based probes (ABPs) for profiling enzyme activity and studying metabolic pathways.
• Material Science Functionalization: Used to derivatize surfaces and nanomaterials with bioactive ligands for sensor development and targeted delivery systems.

Basic Information

Product Name	3,5-Dibromo-2-Chlorosalicylanilide-4'-Isothiocyanate
CAS No.	72670-62-3
Molecular Formula	C14H7Br2ClN2O2S
Molecular Weight	478.54 g/mol
Synonyms	4'-Isothiocyanato-3,5-dibromo-2-chlorosalicylanilide; 2-Chloro-3,5-dibromo-N-(4-isothiocyanatophenyl)salicylamide; 3,5-Dibromo-2-chloro-4'-isothiocyanatosalicylanilide; DBCT; Salicylanilide, 3,5-dibromo-2-chloro-, 4'-isothiocyanate; NSC 403169; Covalent Probe Intermediate DBCT
EINECS	Contact for details

Quality Control

Every batch of 3,5-Dibromo-2-Chlorosalicylanilide-4'-Isothiocyanate is manufactured and tested under strict quality management systems. We ensure high purity and consistency suitable for sensitive research and diagnostic applications. Comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), is performed. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under anhydrous conditions, preferably with desiccant, to prevent hydrolysis of the reactive isothiocyanate group. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.