Description

5-Methylaminomethyluridine is a modified nucleoside building block of significant interest in advanced biochemical research and development. Its primary value lies in its role as a precursor for synthesizing oligonucleotides with tailored properties, enabling the study and manipulation of RNA structure and function. This compound is essential for researchers and manufacturers in the fields of therapeutic oligonucleotide development, diagnostic probe design, and fundamental molecular biology.

Application

• Therapeutic Oligonucleotide Synthesis: A key raw material for producing modified RNA strands used in antisense, siRNA, and mRNA-based therapies.
• Diagnostic Probe Manufacturing: Used to create high-specificity probes for detecting RNA targets in clinical and research diagnostics.
• Biochemical Research: Serves as a critical reagent for studying RNA modification, stability, and protein-RNA interactions.
• Nucleoside Analogue Development: Acts as a precursor for developing novel nucleoside analogues with potential antiviral or anticancer activity.
• Labeled Nucleotide Production: A starting point for synthesizing fluorescence- or radio-labeled nucleotides for tracking and imaging applications.
• CRISPR and Gene Editing Research: Utilized in the synthesis of guide RNAs (gRNAs) with enhanced nuclease resistance and binding affinity.

Basic Information

Product Name	5-Methylaminomethyluridine
CAS No.	72667-55-1
Molecular Formula	C11H17N3O6
Molecular Weight	287.27 g/mol
Synonyms	5'-Methylaminomethyluridine; 5-(Methylaminomethyl)uridine; 5-MAMU; N5-Methyl-5-carboxymethyluridine (related isomer); Uridine, 5-(methylaminomethyl)-; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-5-(methylaminomethyl)pyrimidine-2,4-dione
EINECS	Contact for details

Quality Control

Our 5-Methylaminomethyluridine is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to a robust quality management system to support our commitment to supplying reliable, high-grade biochemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.