Description

L-2-Chloroadenosine (9-(β-L-Ribofuranosyl)-2-Chloro-6-Aminopurine) is a chemically modified nucleoside analog, a key building block in medicinal chemistry and biochemical research. Its value lies in its role as a potent and selective agonist for adenosine receptors, making it a critical intermediate for developing novel therapeutics and research tools. This compound is essential for pharmaceutical R&D teams, academic researchers, and fine chemical manufacturers focused on neurology, cardiology, and oncology applications. The product is supplied to the global market with a focus on high purity and batch-to-batch consistency.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel adenosine receptor-targeting drugs for neurological and cardiovascular disorders.
• Biochemical Research: Used as a selective A1 and A3 adenosine receptor agonist in pharmacological studies and signal transduction pathway analysis.
• Medicinal Chemistry: A versatile scaffold for structure-activity relationship (SAR) studies to develop more potent and selective therapeutic agents.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Nucleoside Chemistry: Used in academic and industrial research to explore novel nucleoside modifications and their biological activities.
• Preclinical Development: Integral in the early-stage development of potential drug candidates targeting inflammatory and ischemic conditions.

Basic Information

Product Name	L-2-Chloroadenosine
CAS No.	72635-67-7
Molecular Formula	C10H12ClN5O4
Molecular Weight	301.69 g/mol
Synonyms	9-(β-L-Ribofuranosyl)-2-chloro-6-aminopurine; 2-Chloro-L-adenosine; L-2-Cl-Ado; 2-Chloroadenosine L-isomer; (1S,2R,3S,4R)-2-(2-Chloro-6-aminopurin-9-yl)-5-(hydroxymethyl)cyclopentane-1,3,4-triol; 2-Chloro-9-β-L-ribofuranosyl-9H-purin-6-amine
EINECS	Contact for details

Quality Control

Our L-2-Chloroadenosine is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or production standards. Specifications can be tailored to meet specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.