Description

5,6-Dichloro-1-Ribofuranosylbenzimidazole 5'-Monophosphate is a specialized nucleotide analog of significant interest in biochemical and pharmaceutical research. Its core value lies in its role as a potent and selective inhibitor of specific kinases, making it a critical tool for studying cellular signaling pathways and enzyme function. This compound is primarily needed by research institutions and pharmaceutical companies engaged in drug discovery, enzymology studies, and the development of novel therapeutic agents targeting kinase-related diseases.

Application

• Biochemical Research: As a key inhibitor for studying protein kinase CK2 (Casein Kinase 2) activity and its role in cellular processes.
• Pharmaceutical Development: Serves as a lead compound or a pharmacophore model for designing new kinase-targeted therapeutics in oncology and inflammatory diseases.
• Enzymology Studies: Used to investigate ATP-binding sites and the mechanism of action of various phosphotransferase enzymes.
• Cell Signaling Pathway Analysis: A vital tool for modulating and understanding intracellular signal transduction cascades in model cell lines.
• Antiviral Research: Explored for potential activity against viruses that utilize host cell kinases for replication.
• Academic Research: Employed in university and institutional labs for fundamental research in molecular biology and chemical biology.

Basic Information

Product Name	5,6-Dichloro-1-Ribofuranosylbenzimidazole 5'-Monophosphate
CAS No.	72586-79-9
Molecular Formula	C12H12Cl2N2O8P
Molecular Weight	405.11 g/mol
Synonyms	5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole 5'-monophosphate; DRB 5'-Monophosphate; 5,6-Dichloro-1-(β-D-ribofuranosyl)benzimidazole 5'-phosphate; CK2 Inhibitor DRB-MP; Nucleotide analog DRB-MP; 1-(β-D-Ribofuranosyl)-5,6-dichlorobenzimidazole 5'-phosphate; 5,6-DCl-1-ribofuranosylbenzimidazole 5'-monophosphate
EINECS	Contact for details

Quality Control

Our 5,6-Dichloro-1-Ribofuranosylbenzimidazole 5'-Monophosphate is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management standards, and our analytical methods, including HPLC and NMR, are validated to provide reliable specifications for the research community.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep the primary container sealed under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 3.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Biological Activity (CK2 Inhibition IC50)	Provided on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.