Description

(3A,5B,12A)-23-Carboxy-12-Hydroxy-24-Norcholan-3-Yl B-D-Glucopyranosiduronic Acid is a high-purity, complex bile acid derivative and glucuronide conjugate, serving as a critical reference standard and advanced pharmaceutical intermediate. Its value lies in enabling precise analytical quantification and supporting the development of novel therapeutic agents targeting metabolic and hepatic pathways. This compound is essential for research institutions, analytical laboratories, and pharmaceutical companies engaged in steroid metabolism studies, drug discovery, and the production of high-value active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative analysis of bile acids and their metabolites in biological samples via HPLC, LC-MS, or GC-MS.
• Drug Discovery & Development: Serves as a key intermediate or building block in the synthesis of novel therapeutic agents for liver and metabolic disorders.
• Metabolic Pathway Research: A vital tool for studying the glucuronidation process, enterohepatic circulation, and the role of bile acids in human physiology and disease.
• Diagnostic Kit Manufacturing: Incorporated into enzyme-linked immunosorbent assay (ELISA) kits and other in-vitro diagnostic (IVD) reagents for clinical testing.
• Biochemical Research: Employed in enzymatic studies to investigate substrate specificity and inhibition of enzymes like β-glucuronidase.
• Quality Control (QC) in API Production: Acts as a critical benchmark for purity and identity testing during the manufacturing of related steroid-based pharmaceuticals.

Basic Information

Product Name	(3A,5B,12A)-23-Carboxy-12-Hydroxy-24-Norcholan-3-Yl B-D-Glucopyranosiduronic Acid
CAS No.	72504-58-6
Molecular Formula	C31H48O11
Molecular Weight	596.71 g/mol
Synonyms	12α-Hydroxy-3α-(β-D-glucopyranosiduronic acid)-5β-cholan-24-oic Acid; 12α-Hydroxy-3α-(β-D-glucopyranosiduronic acid)-5β-cholanic Acid; 3α-Glucuronyl-12α-hydroxy-5β-cholan-24-oic Acid; 12α-Hydroxylithocholic Acid 3-O-β-D-Glucuronide; Norcholanic Acid Glucuronide Derivative; Hyocholic Acid 3-O-Glucuronide (related); Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our (3A,5B,12A)-23-Carboxy-12-Hydroxy-24-Norcholan-3-Yl B-D-Glucopyranosiduronic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or production standards. Specifications can be aligned with USP/Pharma-grade requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This compound is hygroscopic (moisture-sensitive); the container must be kept in a dry environment and allowed to equilibrate to room temperature before opening to prevent condensation. For short-term use (under one month), storage at 2-8°C is acceptable.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.