Description

2,4-Difluorobenzoyl Chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic introduction of fluorine atoms and a reactive acyl chloride group, enabling precise molecular modifications that are essential for developing high-performance materials and active pharmaceutical ingredients. This compound is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for creating novel compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a difluorobenzoyl moiety to modulate bioavailability, metabolic stability, and receptor binding affinity.
• Agrochemical Synthesis: Used in manufacturing advanced herbicides, fungicides, and pesticides, where the fluorine atoms contribute to improved lipophilicity and biological activity.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorine-containing aromatic cores in electronic materials, enhancing thermal stability, optical properties, and charge transport characteristics.
• Polymer & Resin Modifier: Employed to introduce fluorinated aromatic units into polymer chains, improving chemical resistance, thermal stability, and surface properties of high-performance plastics and coatings.
• Organic Synthesis Reagent: A fundamental reagent for Friedel-Crafts acylation, amide bond formation, and esterification reactions in research and process chemistry.
• Dye & Pigment Manufacturing: Used in the synthesis of specialized fluorinated dyes and pigments that offer superior lightfastness and color stability.

Basic Information

Product Name	2,4-Difluorobenzoyl Chloride
CAS No.	72482-64-5
Molecular Formula	C7H3ClF2O
Molecular Weight	176.55 g/mol
Synonyms	2,4-Difluorobenzoyl chloride; Benzoyl chloride, 2,4-difluoro-; 2,4-Difluorobenzoic acid chloride; 2,4-DFBC; 2,4-Difluorobenzoic acid, chloride; α,2,4-Trifluorotoluene (obsolete); 2,4-Difluorobenzoylchlorid; 72482-64-5
EINECS	Contact for details

Quality Control

Our 2,4-Difluorobenzoyl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including assay by GC/HPLC, identity confirmation (IR, NMR), and impurity profiling. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements, including ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 15-25°C. Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent hydrolysis. Keep away from strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.