Description

6-Quinolinecarbonyl chloride is a versatile and highly reactive acyl chloride derivative of quinoline, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to efficiently introduce the quinolinecarbonyl moiety, enabling the construction of complex molecules with tailored properties for high-value applications. This intermediate is essential for research and production in the pharmaceutical, agrochemical, and material science industries, where it is used to create active pharmaceutical ingredients (APIs), functional ligands, and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in developing quinoline-based therapeutics with potential antimicrobial, anticancer, or anti-inflammatory activity.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and fungicides that incorporate the quinoline scaffold for enhanced efficacy.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in coordination chemistry and homogeneous catalysis.
• Material Science Research: Employed in the development of organic semiconductors, light-emitting materials, and other functional polymers where the quinoline unit imparts specific electronic or optical properties.
• Chemical Biology Probes: Useful for labeling biomolecules or creating activity-based probes for studying biological processes.
• Custom Synthesis and R&D: A valuable reagent for contract research organizations (CROs) and academic laboratories exploring new synthetic methodologies and compound libraries.

Basic Information

Product Name	6-Quinolinecarbonyl Chloride
CAS No.	72369-87-0
Molecular Formula	C10H6ClNO
Molecular Weight	191.61 g/mol
Synonyms	Quinoline-6-carbonyl chloride; 6-Carboxyquinoline chloride; 6-Quinolinecarboxylic acid chloride; 6-Quinolylcarbonyl chloride; 6-Quinoline carbonyl chloride; 6-Quinolinecarbonylchloride; 6-Quinoline carboxylic acid chloride
EINECS	Contact for details

Quality Control

Our 6-Quinolinecarbonyl Chloride is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and FTIR, to ensure high purity and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming identity, assay, and impurity profiles. Our quality system is designed to meet the stringent requirements of cGMP and ISO standards for fine chemical production, ensuring reliability for your critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent derivative, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition from moisture ingress. Keep away from heat, open flames, and incompatible materials such as bases, alcohols, and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.