Description

Polyethylene Glycol, Disulfobutyl Ether, Disodium Salt is a functionalized PEG derivative designed for advanced bioconjugation and crosslinking applications. This compound matters for its ability to introduce stable, hydrophilic, and cleavable linkages, enhancing the solubility and pharmacokinetic properties of biomolecules. It is primarily needed by researchers and manufacturers in the pharmaceutical and biotechnology sectors for developing next-generation therapeutics, including antibody-drug conjugates (ADCs) and targeted drug delivery systems.

Application

• Bioconjugation Reagent: For the site-specific modification of proteins, peptides, and antibodies to improve stability and reduce immunogenicity.
• ADC (Antibody-Drug Conjugate) Linker: Serves as a cleavable, hydrophilic spacer between the cytotoxic payload and the targeting antibody.
• Polymer Therapeutics: As a building block for creating smart, stimuli-responsive drug delivery polymers and hydrogels.
• Surface Functionalization: For modifying nanoparticles, quantum dots, and diagnostic agents to enhance biocompatibility and targeting.
• Crosslinking Agent: Used in the preparation of biomaterials and matrices for tissue engineering and 3D cell culture.
• Research & Development: A critical tool in life science research for studying protein interactions, cell signaling, and drug release mechanisms.

Basic Information

Product Name	Polyethylene Glycol, Disulfobutyl Ether, Disodium Salt
CAS No.	72361-57-0
Molecular Formula	C2n+8H4n+14Na2On+4S2 (n = PEG chain length)
Molecular Weight	Variable (dependent on PEG chain length). Contact for details.
Synonyms	PEG-Disulfobutyl Ether Disodium Salt; Disodium PEGylated Disulfobutyl Ether; Disulfobutyl PEG Ether Disodium Salt; Bis-sulfobutyl PEG Ether Disodium Salt; mPEG-SS-Bu-ONa; Cleavable PEG Linker Disodium Salt; Sodium 4,4'-disulfanediyldibutoxy polyethylene glycol; Poly(oxy-1,2-ethanediyl), α,ω-bis[(4-sulfobutyl)thio]-, sodium salt (1:2)
EINECS	Contact for details

Quality Control

Our Polyethylene Glycol, Disulfobutyl Ether, Disodium Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and assay, NMR for structural confirmation, and mass spectrometry for molecular weight verification. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake. For long-term storage, consider desiccant and under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
PEG Average Molecular Weight	As per order (e.g., 2kDa, 5kDa, 10kDa, 20kDa)
Polydispersity Index (PDI)	≤ 1.05
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Disulfide Bond Purity	≥ 98%
Endotoxin (LAL)	< 0.1 EU/mg (for injectable grades)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.