Description

2-Chloroadenosine-5'-Carboxy-2',3'-Acetonide is a key nucleoside derivative and a protected intermediate used in advanced organic synthesis. This compound is of significant value for researchers and manufacturers developing novel pharmaceutical agents, particularly in the fields of antiviral and anticancer drug discovery. It is primarily utilized by the pharmaceutical, biotechnology, and fine chemical synthesis industries for the preparation of modified nucleotides and nucleoside analogs.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel nucleoside-based therapeutics, including potential antiviral and anticancer agents.
• Biochemical Research: Used as a substrate or precursor in enzymatic studies and for investigating nucleotide-related biological pathways.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex, high-value specialty chemicals and labeled compounds for research.
• Prodrug Development: The acetonide-protected carboxyl group makes it a valuable intermediate for designing prodrugs with improved bioavailability.

Basic Information

Product Name	2-Chloroadenosine-5'-Carboxy-2',3'-Acetonide
CAS No.	72209-20-2
Molecular Formula	C14H14ClN5O5
Molecular Weight	367.75 g/mol
Synonyms	2-Chloro-9-[(2R,3R,4R,5R)-3,4-dihydroxy-5-[(hydroxymethyl)oxolan-2-yl]purin-6-yl]acetic acid 2,2-dimethyl-1,3-dioxolane-4-yl ester; 2-Chloroadenosine 5'-carboxylic acid 2',3'-isopropylidene ester; 2-Cl-Ado-5'-COOH-2',3'-acetonide; 2-Chloro-9-(2,3-O-isopropylidene-β-D-ribofuranosyl)adenine-5'-carboxylic acid; 2-Chloroadenosine-5'-carboxylic acid 2',3'-O-isopropylidene derivative
EINECS	Contact for details

Quality Control

Our 2-Chloroadenosine-5'-Carboxy-2',3'-Acetonide is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research and synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant standards for pharmaceutical intermediates, and specifications can be aligned with customer requirements for specific projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥95.0%
Purity (HPLC, Area %)	≥97.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.