Description

5'(R)-C-Methyluridine is a high-purity, modified nucleoside building block of significant interest in advanced pharmaceutical research and development. Its unique stereochemistry at the 5'-carbon position makes it a critical intermediate for the synthesis of novel nucleoside analogs and oligonucleotides. This compound is essential for researchers and manufacturers in the fields of antiviral drug discovery, mRNA vaccine development, and medicinal chemistry, where precise molecular structure is paramount for biological activity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used in the research and production of modified RNA strands for therapeutic and diagnostic applications.
• Medicinal Chemistry & Drug Discovery: A vital scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism and processing.
• mRNA Technology: Potential use in the development of next-generation mRNA therapeutics with enhanced stability and translational efficiency.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory compliance in API manufacturing.

Basic Information

Product Name	5'(R)-C-Methyluridine
CAS No.	72159-54-7
Molecular Formula	C10H14N2O6
Molecular Weight	258.23 g/mol
Synonyms	5'-C-Methyluridine (R-isomer); (5'R)-5'-C-Methyluridine; 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidine-2,4-dione; Uridine, 5'-C-methyl-, (5'R)-; 5'-Methyluridine (ambiguous); Modified Nucleoside; RNA Building Block
EINECS	Contact for details

Quality Control

Our 5'(R)-C-Methyluridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and cGMP applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥98% by HPLC), and impurity profiles. We adhere to relevant industry guidelines to support your regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.