Description

1H-Indazole-3-Carbonyl Chloride is a high-value, reactive chemical intermediate essential for advanced organic synthesis. Its primary commercial value lies in its role as a versatile building block for constructing complex heterocyclic compounds, particularly in the pharmaceutical sector. This compound is critically needed by research and development chemists and process scale-up teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of various drug candidates, particularly those containing the indazole scaffold, which is prevalent in kinase inhibitors and other therapeutic agents.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides, where the indazole moiety can contribute to biological activity.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of advanced polymers and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a reactive handle for labeling proteins or synthesizing activity-based probes for enzyme studies.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological development and the exploration of new chemical spaces.
• Custom Synthesis & Scale-Up: Critical for contract manufacturing organizations (CMOs) performing custom synthesis and process optimization for client molecules.

Basic Information

Product Name	1H-Indazole-3-Carbonyl Chloride
CAS No.	72083-74-0
Molecular Formula	C8H5ClN2O
Molecular Weight	180.59 g/mol
Synonyms	1H-Indazole-3-carbonyl chloride; Indazole-3-carbonyl chloride; 3-Carboxyindazole chloride; 1H-Indazole-3-carboxylic acid chloride; 3-Indazolecarbonyl chloride; 72083-74-0; Indazole-3-Carbonyl Chloride; 1H-Indazole-3-carboxyl chloride
EINECS	Contact for details

Quality Control

Our 1H-Indazole-3-Carbonyl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically verified by HPLC, NMR, and IR spectroscopy. We adhere to relevant industry standards and can support development under cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and reactive acid chloride nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.