Description

n-[(3A,5B,7A,12A)-3,12-Dihydroxy-24-Oxo-7-(Sulfooxy)Cholan-24-Yl]-Glycine is a chemically modified bile acid derivative, specifically a glycine conjugate of a sulfated and oxidized cholanic acid. This compound is of significant interest in pharmaceutical research and development due to its potential role in modulating biological pathways related to lipid metabolism and cellular signaling. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents, metabolic studies, and biochemical research.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel steroidal drugs and targeted therapeutics.
• Biochemical Research: Used as a reference standard or probe in studies of bile acid metabolism, receptor interactions, and enzyme function.
• Metabolic Pathway Analysis: Employed in in-vitro and in-vivo studies to investigate the role of sulfated and glycine-conjugated bile acids.
• Drug Discovery: Serves as a precursor or analog in medicinal chemistry programs targeting nuclear receptors like FXR (Farnesoid X Receptor).
• Diagnostic Agent Development: Potential use in developing contrast agents or biomarkers for diagnostic imaging.

Basic Information

Product Name	n-[(3A,5B,7A,12A)-3,12-Dihydroxy-24-Oxo-7-(Sulfooxy)Cholan-24-Yl]-Glycine
CAS No.	71977-73-6
Molecular Formula	C₂₆H₄₁NO₁₀S
Molecular Weight	559.68 g/mol
Synonyms	Glyco-7-sulfo-3,12-dihydroxy-24-oxocholanic acid; 7-Sulfoglycochenodeoxycholic acid derivative; 3α,7α,12α-Trihydroxy-24-oxo-5β-cholan-24-oic acid 7-sulfate glycine conjugate; Tauro-7-sulfolithocholic acid analog; N-(3α,12α-Dihydroxy-24-oxo-7α-sulfooxy-5β-cholan-24-yl)glycine; 7-Sulfooxychenodeoxycholylglycine; Glycine conjugate of 7-sulfated 3,12-dihydroxy-24-oxo-5β-cholan-24-oic acid
EINECS	Contact for details

Quality Control

Our n-[(3A,5B,7A,12A)-3,12-Dihydroxy-24-Oxo-7-(Sulfooxy)Cholan-24-Yl]-Glycine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.