Description

(3A,5B,7A,12B)-3,7,12-Trihydroxy-Cholan-24-Oic Acid is a high-purity, multi-hydroxylated bile acid derivative, serving as a critical intermediate and reference standard in advanced pharmaceutical research and development. Its defined stereochemistry and functional groups make it invaluable for the synthesis of novel therapeutic agents and for metabolic pathway studies. This compound is essential for R&D laboratories and production facilities in the pharmaceutical and biotechnology sectors focused on hepatology, gastroenterology, and metabolic disorders.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of specialized bile acid analogs and hepatoprotective drugs.
• Reference Standard: Used in analytical chemistry for method development, validation, and quality control (QC) of related pharmaceutical products.
• Biochemical Research: Employed in studies of bile acid metabolism, liver function, and membrane biology.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in the development of new APIs targeting cholestatic liver diseases.
• Metabolite Standard: Critical for quantitative analysis in pharmacokinetic and metabolomic studies.

Basic Information

Product Name	(3A,5B,7A,12B)-3,7,12-Trihydroxy-Cholan-24-Oic Acid
CAS No.	71883-64-2
Molecular Formula	C24H40O5
Molecular Weight	408.57 g/mol
Synonyms	3α,7α,12α-Trihydroxy-5β-cholan-24-oic Acid; Trihydroxycoprostanic Acid; Cholanoic Acid, 3,7,12-trihydroxy-, (3α,5β,7α,12α)-; 3,7,12-Trihydroxycholanoic Acid; 5β-Cholan-24-oic Acid-3α,7α,12α-triol; 3α,7α,12α-Trihydroxy-5β-cholanic Acid
EINECS	Contact for details

Quality Control

Our (3A,5B,7A,12B)-3,7,12-Trihydroxy-Cholan-24-Oic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) documenting all critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.