Description

Adenosine-3',5'-Cyclic Monophosphorothioate is a chemically modified, phosphorothioate analog of cyclic adenosine monophosphate (cAMP), a fundamental secondary messenger in cellular signaling. This sulfur-for-oxygen substitution at the phosphate backbone confers enhanced resistance to hydrolysis by phosphodiesterases, making it a crucial tool for sustained activation of cAMP-dependent pathways in biochemical research. It is primarily utilized by researchers and manufacturers in the life sciences sector for studying protein kinase A (PKA) signaling, ion channel regulation, and other critical physiological processes.

Application

• Biochemical Research: As a stable, cell-permeable cAMP analog for investigating intracellular signal transduction mechanisms.
• Pharmaceutical R&D: A key reference standard and tool compound in drug discovery programs targeting G-protein-coupled receptors (GPCRs) and downstream effectors.
• Enzyme Studies: Used as a substrate or inhibitor in assays for phosphodiesterases and to study the specificity of protein kinases.
• Cell Biology: Employed to modulate cellular functions such as gene expression, metabolism, and secretion in various cell culture models.
• Diagnostic Development: Serves as a critical component in the development of immunoassays and other diagnostic kits for cAMP pathway analysis.

Basic Information

Product Name	Adenosine-3',5'-Cyclic Monophosphorothioate
CAS No.	71774-13-5
Molecular Formula	C10H12N5O5PS
Molecular Weight	345.27 g/mol
Synonyms	cAMPS; Adenosine 3',5'-cyclic monophosphorothioate; Cyclic AMP phosphorothioate; cAMP-S; Rp-cAMPS; 8-(4-Chlorophenylthio)adenosine-3',5'-cyclic monophosphorothioate (isomer-specific); Sp-cAMPS; Adenosine cyclic 3',5'-(hydrogen phosphorothioate)
EINECS	Contact for details

Quality Control

Every batch of Adenosine-3',5'-Cyclic Monophosphorothioate is produced and tested under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or moisture will compromise stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.