Description

Methotrexate-γ-Dimethylamide is a chemically modified derivative of the antifolate agent methotrexate, designed to alter its pharmacological profile. This compound is of significant interest in pharmaceutical research and development for creating novel therapeutic agents. It serves as a critical intermediate or reference standard for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those focused on oncology and autoimmune disease treatment.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel methotrexate analogs and prodrugs for targeted therapy development.
• Biochemical Research: Used as a reference standard or inhibitor in enzymatic studies, particularly those investigating dihydrofolate reductase (DHFR) and other folate pathway enzymes.
• Drug Discovery: Acts as a core scaffold in medicinal chemistry programs aimed at improving drug efficacy, selectivity, or reducing toxicity profiles.
• Analytical Standard: Employed as a high-purity calibrant in analytical methods such as HPLC and LC-MS for quality control and metabolic studies.
• Preclinical Development: Utilized in in vitro and in vivo studies to evaluate the pharmacokinetics and pharmacodynamics of modified antifolate compounds.

Basic Information

Product Name	Methotrexate-γ-Dimethylamide
CAS No.	71074-44-7
Molecular Formula	C₂₂H₂₈N₈O₅
Molecular Weight	484.51 g/mol
Synonyms	N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-γ-dimethyl-L-glutamic acid diamide; MTX-γ-DMA; L-Glutamine, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-N,N-dimethyl-, (S)-; Methotrexate γ-dimethylamide; 4-Amino-10-methylpteroyl-γ-dimethylglutamate; Amethopterin γ-dimethylamide
EINECS	Contact for details

Quality Control

Our Methotrexate-γ-Dimethylamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with detailed specifications for traceability and regulatory support, ensuring compliance with research and development grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.