Description

2-Chloro-4-Fluorophenyl Isothiocyanate is a versatile and reactive aromatic isothiocyanate derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the introduction of both the reactive isothiocyanate group and halogen substituents, enabling precise molecular construction for high-value intermediates. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of thiourea derivatives and heterocyclic compounds with potential biological activity.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and insecticides that leverage its halogenated aromatic structure.
• Material Science Research: Used in the creation of functional polymers and advanced materials where the isothiocyanate group facilitates cross-linking or surface modification.
• Chemical Biology & Proteomics: Acts as an electrophilic probe for labeling cysteine residues in proteins or as a scaffold for activity-based protein profiling (ABPP) reagents.
• Dye & Pigment Intermediate: Serves in the synthesis of specialized dyes and colorants requiring halogen and sulfur-containing functionalities.

Basic Information

Product Name	2-Chloro-4-Fluorophenyl Isothiocyanate
CAS No.	71048-69-6
Molecular Formula	C7H3ClFNS
Molecular Weight	187.62 g/mol
Synonyms	1-Chloro-2-fluoro-4-isothiocyanatobenzene; (2-Chloro-4-fluorophenyl) isothiocyanate; 2-Chloro-4-fluoro-1-isothiocyanatobenzene; 2-Chloro-4-fluorophenyl mustard oil; Isothiocyanic acid, 2-chloro-4-fluorophenyl ester; 4-Fluoro-2-chlorophenyl isothiocyanate
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Fluorophenyl Isothiocyanate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed when not in use and stored away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.