Description

R-Doxazosin is a high-purity enantiomer of the selective α-1 adrenergic receptor antagonist doxazosin. This compound is of significant value in pharmaceutical research and development, particularly for studying stereospecific drug-receptor interactions and metabolic pathways. It is essential for researchers and manufacturers in the pharmaceutical and fine chemical sectors who require precise chiral building blocks for advanced drug discovery and process development.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control of doxazosin-based drug products.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of enantiomerically pure pharmaceutical compounds.
• Metabolic and Pharmacokinetic Studies: Employed in preclinical and clinical research to investigate the distinct absorption, distribution, metabolism, and excretion (ADME) profile of the R-enantiomer.
• Analytical Chemistry: Utilized as a high-purity standard for calibrating instruments like HPLC and LC-MS in forensic and regulatory testing laboratories.
• Academic and Institutional Research: Applied in biochemical and pharmacological studies to understand the mechanistic action of α-adrenergic blockers at a molecular level.

Basic Information

Product Name	R-Doxazosin
CAS No.	70918-17-1
Molecular Formula	C23H25N5O5
Molecular Weight	451.48 g/mol
Synonyms	(R)-Doxazosin; (R)-(-)-Doxazosin; Doxazosin R-Enantiomer; (2R)-1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazine; 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2R)-2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl]piperazine; Cardura R-Enantiomer; CAS 74163-81-8 (Mesylate salt)
EINECS	Contact for details

Quality Control

Our R-Doxazosin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research materials. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results for chiral purity, assay, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant use and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (Chiral HPLC)	≥99.0% (R-Enantiomer)
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.