Description

Doxazosin Hydrochloride is a high-purity, selective α-1 adrenergic receptor antagonist used primarily as an active pharmaceutical ingredient (API). Its core value lies in its critical role in the formulation of antihypertensive and benign prostatic hyperplasia (BPH) medications, ensuring therapeutic efficacy and batch-to-batch consistency. This compound is essential for pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in cardiovascular and urological drug production.

Application

• Pharmaceutical API: Primary use as the active ingredient in finished dosage forms for the treatment of hypertension and benign prostatic hyperplasia (BPH).
• Generic Drug Manufacturing: Sourcing for the production of generic doxazosin mesylate and hydrochloride tablets.
• Clinical Research: Utilization in preclinical and clinical studies for cardiovascular and urological research.
• Reference Standard: Serves as a high-purity chemical reference standard for quality control and analytical method development in laboratories.
• Formulation Development: Used in R&D for developing new drug delivery systems and combination therapies.
• Contract Manufacturing: Supply to CDMOs for the production of specialized and regulated pharmaceutical products.

Basic Information

Product Name	Doxazosin Hydrochloride
CAS No.	70918-01-3
Molecular Formula	C23H25N5O5 • HCl
Molecular Weight	487.94 g/mol
Synonyms	Doxazosin HCl; UK-33274; Doxazosin Hydrochloride Anhydrous; 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazine Monohydrochloride; 4-Amino-2-[4-(1,4-benzodioxan-2-ylcarbonyl)piperazin-1-yl]-6,7-dimethoxyquinazoline Hydrochloride; Cardura (brand name reference); Alfadil (brand name reference)
EINECS	Contact for details

Quality Control

Our Doxazosin Hydrochloride is manufactured and tested under strict quality management systems. We provide material that meets or exceeds relevant pharmacopeial standards, including USP and EP monographs where applicable. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles to ensure compliance with your specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Microbial Limits	Meets USP <61> and <62> requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.