Description

Diethyl (Cbz-Aminomethyl)Phosphonate is a high-value organophosphorus building block, specifically a protected aminomethylphosphonate ester. This compound is essential for its role in the synthesis of phosphonopeptides and other biologically active molecules, serving as a key precursor for introducing the phosphonate moiety. It is primarily sought after by research institutions and pharmaceutical companies engaged in medicinal chemistry, particularly for the development of enzyme inhibitors and prodrugs.

Application

• Phosphonopeptide Synthesis: A crucial intermediate for constructing peptide analogs where a carboxylic acid is replaced by a phosphonic acid group, enhancing metabolic stability.
• Medicinal Chemistry & Drug Discovery: Used in the research and development of protease inhibitors, antibacterial agents, and other therapeutic candidates targeting phosphate-binding sites.
• Organocatalyst & Ligand Preparation: Serves as a precursor for chiral aminophosphonic acids and their derivatives, which can function as catalysts or ligands in asymmetric synthesis.
• Chemical Biology Probes: Employed to create activity-based probes and molecular tools for studying enzymatic mechanisms and biological pathways.
• Material Science: Potential monomer or additive for creating functional polymers with specific metal-chelating or surface-modifying properties.

Basic Information

Product Name	Diethyl (Cbz-Aminomethyl)Phosphonate
CAS No.	70908-61-1
Molecular Formula	C₁₃H₂₀NO₅P
Molecular Weight	301.27 g/mol
Synonyms	Diethyl N-[(Benzyloxy)carbonyl]aminomethylphosphonate; Diethyl [(Benzyloxycarbonylamino)methyl]phosphonate; (Cbz-Aminomethyl)phosphonic Acid Diethyl Ester; N-Cbz-Aminomethylphosphonic Acid Diethyl Ester; Z-Aminomethylphosphonic Acid Diethyl Ester; NSC 334368; Carbobenzoxyaminomethylphosphonic Acid Diethyl Ester
EINECS	Contact for details

Quality Control

Our Diethyl (Cbz-Aminomethyl)Phosphonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.