Description

3'',5''-Dibenzoylthymidine is a key thymidine derivative where the 3' and 5' hydroxyl groups are protected as benzoate esters. This compound matters as a crucial protected intermediate in the synthesis of nucleoside analogs, antiviral agents, and oligonucleotides, enabling precise chemical modifications. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions focused on developing novel therapeutics and molecular probes.

Application

• Pharmaceutical Intermediate: A vital building block in the synthesis of modified nucleosides and nucleotide-based antiviral or anticancer drugs.
• Oligonucleotide Synthesis: Used as a protected monomer in solid-phase and solution-phase synthesis of DNA and RNA analogs.
• Biochemical Research: Serves as a precursor for labeled nucleosides used in metabolic studies and diagnostic assays.
• Prodrug Development: The benzoyl protecting groups can be utilized in prodrug strategies to enhance the bioavailability of active nucleoside agents.
• Chemical Biology: Employed in the creation of molecular tools and probes for studying enzyme mechanisms and nucleic acid interactions.

Basic Information

Product Name	3'',5''-Dibenzoylthymidine
CAS No.	70838-47-0
Molecular Formula	C25H24N2O8
Molecular Weight	480.47 g/mol
Synonyms	Thymidine 3',5'-Dibenzoate; 1-[(2R,4S,5R)-4-Benzoyloxy-5-(benzoyloxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione; 3',5'-Di-O-benzoylthymidine; 3',5'-Dibenzoylthymidine; 2'-Deoxythymidine 3',5'-dibenzoate; NSC 401005; 3,5-Dibenzoylthymidine
EINECS	Contact for details

Quality Control

Our 3'',5''-Dibenzoylthymidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.