Description

Cyclobutanecarbonyl Chloride, 1-Methyl-2-(1-Methylethenyl)-, cis- (9Ci) CAS NO 70645-45-3 is a specialized, high-purity organic intermediate featuring a reactive acid chloride functional group on a substituted cyclobutane ring. This compound is valued for its unique sterically defined structure, which makes it a critical building block for synthesizing complex molecules with specific three-dimensional configurations. It is primarily sought after by research and development chemists and process scale-up teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and production of novel active pharmaceutical ingredients (APIs), particularly those requiring a rigid, substituted cyclobutane core.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the cis-configuration imparts specific biological activity.
• Material Science Research: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers with tailored thermal and mechanical properties.
• Organic Synthesis & Process Chemistry: Employed in academic and industrial labs for method development, including acylations and the construction of complex carbocyclic systems.
• Ligand and Catalyst Development: Utilized to create novel chiral ligands and organocatalysts for asymmetric synthesis applications.
• Fine Chemical Production: Acts as a precursor for other high-value, low-volume specialty chemicals used in electronics and performance materials.

Basic Information

Product Name	Cyclobutanecarbonyl Chloride, 1-Methyl-2-(1-Methylethenyl)-, cis- (9Ci)
CAS No.	70645-45-3
Molecular Formula	C9H13ClO
Molecular Weight	172.65 g/mol
Synonyms	cis-1-Methyl-2-(1-methylethenyl)cyclobutanecarbonyl chloride; (1S,2S)-1-Methyl-2-(prop-1-en-2-yl)cyclobutane-1-carbonyl chloride; 1-Methyl-2-isopropenylcyclobutanecarbonyl chloride, cis-; Cyclobutanecarbonyl chloride, 1-methyl-2-(1-methylethenyl)-, (1S,2S)-rel-; 70645-45-3; cis-1-Methyl-2-isopropenyl-1-cyclobutanecarbonyl chloride
EINECS	Contact for details

Quality Control

Our Cyclobutanecarbonyl Chloride, 1-Methyl-2-(1-Methylethenyl)-, cis- is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All products undergo rigorous analytical testing, including HPLC, GC, NMR, and chiral analysis, to confirm identity, purity, and isomeric composition. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and strong acid/organic solvent nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as bases, alcohols, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% cis-isomer
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.