Description

(5S)-26'-Deoxo-5,28-Dihydro-26'-Thioxo-21-De(1-Carbamoylethenyl)Siomycin A is a structurally modified derivative of the siomycin complex, a class of thiopeptide antibiotics known for their potent biological activity. This compound is of significant interest in pharmaceutical research and development due to its potential as a lead structure for novel antimicrobial agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery of new antibiotics and the study of bacterial protein synthesis inhibition.

Application

• Pharmaceutical Research: Serves as a key intermediate or reference standard in the development of novel thiopeptide-based antibiotics targeting drug-resistant bacteria.
• Mechanistic Studies: Used in biochemical and microbiological assays to investigate the inhibition of protein synthesis, specifically targeting the bacterial ribosome.
• Structure-Activity Relationship (SAR) Analysis: Provides a core scaffold for chemical modification to optimize potency, selectivity, and pharmacokinetic properties of new drug candidates.
• Antimicrobial Agent Development: Evaluated for its efficacy against Gram-positive pathogens, including methicillin-resistant *Staphylococcus aureus* (MRSA) and vancomycin-resistant enterococci (VRE).

Basic Information

Item	Details
Product Name	(5S)-26'-Deoxo-5,28-Dihydro-26'-Thioxo-21-De(1-Carbamoylethenyl)Siomycin A
CAS No.	70591-35-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Siomycin A derivative; 26'-Deoxo-26'-thioxosiomycin A derivative; Thiopeptide antibiotic derivative; Antibiotic SI 3554 derivative; (5S)-21-De(1-carbamoylethenyl)siomycin A thio-derivative; 70591-35-4; 26'-Thioxosiomycin A analog
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research chemicals. Each batch is characterized using advanced analytical techniques to confirm identity and purity. Certificates of Analysis (COA) detailing specific test results are available upon request to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.