Description

2-Isobutyramido Guanosine 2',3',5'-Tris(Isobutanoate) is a chemically modified nucleoside derivative, designed to enhance stability and bioavailability for advanced research and development applications. This compound is critical for pharmaceutical chemists and biochemists working on nucleotide-based therapeutics, where protecting group chemistry is essential. It serves as a key synthetic intermediate or building block for the development of novel antiviral agents, mRNA vaccine components, and other oligonucleotide conjugates.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of modified nucleoside analogs for antiviral and anticancer drug discovery programs.
• Oligonucleotide Synthesis: Used in the preparation of protected guanosine phosphoramidites for solid-phase synthesis of DNA/RNA sequences with enhanced properties.
• Prodrug Development: Serves as a prodrug form of guanosine, where the isobutyrate groups improve cell membrane permeability and metabolic stability.
• Biochemical Research: Employed in studies investigating nucleotide metabolism, enzyme mechanisms, and the structure-activity relationships of nucleoside derivatives.
• mRNA Technology: Potential use as a modified cap analog or in the synthesis of nucleotide monomers for therapeutic mRNA, aiming to improve translation efficiency and reduce immunogenicity.

Basic Information

Product Name	2-Isobutyramido Guanosine 2',3',5'-Tris(Isobutanoate)
CAS No.	70337-80-3
Molecular Formula	C₂₇H₄₀N₆O₁₀
Molecular Weight	608.65 g/mol
Synonyms	Guanosine, 2-(2-methylpropanamido)-, 2',3',5'-tris(2-methylpropanoate); 2'-O-Isobutyryl-3'-O-Isobutyryl-5'-O-Isobutyryl-2-N-Isobutyrylguanosine; N2,2',3',5'-Tetra-O-isobutyrylguanosine; 2-N-Isobutyryl-2',3',5'-tri-O-isobutyrylguanosine; Protected Guanosine; Isobutyryl Guanosine Ester
EINECS	Contact for details

Quality Control

We supply 2-Isobutyramido Guanosine 2',3',5'-Tris(Isobutanoate) with a focus on high purity and batch-to-batch consistency, essential for sensitive pharmaceutical R&D. Our products undergo rigorous quality testing, including HPLC, NMR, and mass spectrometry, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation and an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.