Description

6-S-Methyl-6-Thioguanosine 5'-(Tetrahydrogen Triphosphate) is a chemically modified nucleotide triphosphate analog, a critical building block for advanced biochemical research and development. This compound is essential for studying RNA structure, function, and metabolism, as well as for the development of novel therapeutic agents and diagnostic tools. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on enzymology, molecular biology, and nucleotide-based drug discovery.

Application

• Enzymology Research: Used as a substrate or inhibitor in studies of RNA polymerases, kinases, and other nucleotide-processing enzymes to elucidate catalytic mechanisms.
• RNA Structure Probing: Incorporated into RNA molecules to investigate folding, stability, and ligand interactions via its unique thioguanosine modification.
• Antiviral & Anticancer Drug Development: Serves as a precursor or active metabolite in the synthesis and screening of nucleotide analogs targeting viral replication or cellular proliferation pathways.
• Diagnostic Assay Development: Employed in the creation of sensitive detection kits for enzymatic activity or as a labeled probe in various biochemical assays.
• Metabolic Pathway Studies: Acts as a tracer or modulator to study purine and nucleotide salvage pathways within cells.
• Bioconjugation & Labeling: The reactive thio group provides a handle for site-specific conjugation with fluorophores or other reporter molecules for imaging applications.

Basic Information

Product Name	6-S-Methyl-6-Thioguanosine 5'-(Tetrahydrogen Triphosphate)
CAS No.	70318-62-6
Molecular Formula	C11H18N5O13P3S
Molecular Weight	561.27 g/mol
Synonyms	6-Thioguanosine-5'-triphosphate, S-Methylated; 6-S-Methyl-6-thio-GTP; 6-Methylthio-GTP; m6sGTP; 6-Methylmercaptoguanosine triphosphate; Guanosine, 6-(methylthio)-, 5'-(tetrahydrogen triphosphate); 6-(Methylthio)-9-β-D-ribofuranosylpurine 5'-(tetrahydrogen triphosphate)
EINECS	Contact for details

Quality Control

Our 6-S-Methyl-6-Thioguanosine 5'-(Tetrahydrogen Triphosphate) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, the product should be handled under anhydrous conditions and allowed to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/UV)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water or appropriate buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.