Description

1H-Purine-6-Carbonyl Chloride (9Ci) is a high-value, reactive chemical intermediate primarily used in nucleoside and nucleotide chemistry. Its core value lies in its ability to act as a versatile building block for the synthesis of modified purine derivatives, which are crucial in pharmaceutical and agrochemical research. This compound is essential for researchers and manufacturers in the pharmaceutical industry, particularly those developing antiviral agents, anticancer drugs, and other nucleoside-based therapeutics. The product is supplied under strict quality control to ensure consistency and reliability for critical synthetic applications.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel nucleoside analogs with potential antiviral (e.g., for HIV, hepatitis) and anticancer activity.
• Agrochemical Research: Used in creating novel purine-based plant growth regulators or pesticides.
• Biochemical Probe Development: Serves as a precursor for labeled (e.g., fluorescent, radioactive) nucleotides used in molecular biology and diagnostic assays.
• Academic & Contract Research: Employed in organic synthesis research for constructing complex heterocyclic systems and studying reaction mechanisms.
• Nucleotide Chemistry: Facilitates the introduction of the carbonyl chloride moiety for further derivatization, enabling the creation of custom nucleotides.

Basic Information

Product Name	1H-Purine-6-Carbonyl Chloride (9Ci)
CAS No.	70265-75-7
Molecular Formula	C6H3ClN4O
Molecular Weight	182.57 g/mol
Synonyms	6-Chlorocarbonylpurine; Purine-6-carbonyl chloride; 6-Purinecarbonyl chloride; 1H-Purine-6-carboxylic acid chloride; 9H-Purine-6-carbonyl chloride; 6-(Chloroformyl)-9H-purine; 6-Carboxypurine chloride
EINECS	Contact for details

Quality Control

Our 1H-Purine-6-Carbonyl Chloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) providing batch-specific data is available for every shipment upon request, guaranteeing traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.