Description

Adenosine-2-Carboxamide is a chemically modified nucleoside derivative of adenosine, where a carboxamide group is introduced at the 2-position of the purine ring. This structural modification is significant as it can alter the compound's biological activity and receptor binding profile, making it a valuable intermediate in pharmaceutical research and development. It is primarily needed by researchers and manufacturers in the life sciences sector, particularly those focused on nucleoside chemistry, medicinal chemistry, and the development of potential therapeutic agents targeting adenosine receptors.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel nucleoside-based drug candidates and prodrugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore modifications of adenosine for enhanced potency, selectivity, or metabolic stability.
• Biochemical Research: Employed as a reference standard or probe in studies investigating adenosine receptor (A1, A2A, A2B, A3) signaling pathways and functions.
• Enzyme Substrate/Analog: Potential use as a substrate or inhibitor for enzymes that process natural nucleosides, such as kinases and deaminases.
• Diagnostic Development: Can be utilized in the development of diagnostic assays or imaging agents targeting adenosine-related biological processes.

Basic Information

Product Name	Adenosine-2-Carboxamide
CAS No.	70255-72-0
Molecular Formula	C11H14N6O4
Molecular Weight	294.27 g/mol
Synonyms	2-Carbamoyladenosine; Adenosine-2-carboxylic acid amide; 9-β-D-Ribofuranosyl-2-carboxamidoadenine; 2-Carboxamidoadenosine; 2-CA; 2-CADO (ambiguous, verify context); N6-[(Aminocarbonyl)methyl]adenosine (tautomeric form); 2-(Aminocarbonyl)adenosine
EINECS	Contact for details

Quality Control

Our Adenosine-2-Carboxamide is produced under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Quality is verified through a battery of analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation by atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.