Description

Ethanone, 2,2-Difluoro-1-(4-Methylphenyl)-, Conjugate Acid (9Ci) is a specialized fluorinated aromatic ketone derivative, serving as a key synthetic intermediate. Its value lies in the unique reactivity imparted by the difluoroacetyl group adjacent to the aromatic ring, enabling precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors developing novel active ingredients, particularly where the introduction of fluorine atoms is critical for modulating biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where fluorination enhances lipophilicity and environmental persistence.
• Material Science Research: Serves as a precursor for developing novel fluorinated polymers, liquid crystals, and organic electronic materials with unique optical and electronic properties.
• Organic Synthesis Reagent: Employed in academic and industrial R&D for constructing complex molecules via reactions like Friedel-Crafts acylation, nucleophilic addition, and cross-coupling.
• Fluorine Chemistry Studies: A valuable model compound for investigating the electronic effects and reactivity of gem-difluoro ketone functionalities in aromatic systems.

Basic Information

Product Name	Ethanone, 2,2-Difluoro-1-(4-Methylphenyl)-, Conjugate Acid (9Ci)
CAS No.	70205-36-6
Molecular Formula	C9H8F2O
Molecular Weight	170.16 g/mol
Synonyms	2,2-Difluoro-1-(4-methylphenyl)ethanone; 4-Methyl-2,2-difluoroacetophenone; 1-(4-Methylphenyl)-2,2-difluoroethanone; 2,2-Difluoro-1-p-tolylethanone; p-Tolyl 2,2-difluoroketone; α,α-Difluoro-4-methylacetophenone; Conjugate Acid of 2,2-Difluoro-1-(4-Methylphenyl)ethanone (9CI)
EINECS	Contact for details

Quality Control

Our Ethanone, 2,2-Difluoro-1-(4-Methylphenyl)-, Conjugate Acid (9Ci) is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and consistent performance as a synthetic intermediate. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.