Description

(R)-2-Chloropropionyl Chloride is a high-purity chiral building block and versatile acylating agent. Its value lies in its role as a key intermediate for introducing the (R)-2-chloropropionyl moiety, which is critical for synthesizing enantiomerically pure pharmaceuticals and agrochemicals. This compound is essential for R&D and production chemists in the pharmaceutical, agrochemical, and fine chemical industries who require high stereochemical fidelity for active ingredient development.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the production of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in cardiovascular and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the manufacture of chiral herbicides, fungicides, and pesticides where specific stereochemistry is required for biological activity.
• Asymmetric Synthesis: Serves as a precursor for chiral auxiliaries, catalysts, and resolving agents in stereoselective organic transformations.
• Peptide & Protein Modification: An acylating agent for modifying amino acids, peptides, or other biomolecules to introduce specific functional groups.
• Polymer Chemistry: Monomer or co-monomer for synthesizing specialty polymers with tailored properties, such as chiral stationary phases for chromatography.
• Fine Chemical Production: Intermediate in the multi-step synthesis of complex organic molecules for research and commercial scale-up.

Basic Information

Product Name	(R)-2-Chloropropionyl Chloride
CAS No.	70110-25-7
Molecular Formula	C3H4Cl2O
Molecular Weight	126.97 g/mol
Synonyms	(R)-(-)-2-Chloropropionyl Chloride; (R)-2-Chloropropanoyl Chloride; (R)-α-Chloropropionyl Chloride; (2R)-2-Chloropropanoyl Chloride; (R)-CPC; D-2-Chloropropionyl Chloride; (R)-Chloropropionyl Chloride; (R)-2-Chloro-1-oxopropane
EINECS	Contact for details

Quality Control

Our (R)-2-Chloropropionyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC or GC, to ensure high enantiomeric excess (ee) and chemical purity. Certificates of Analysis (COA) detailing identity, assay, impurity profile, and specific rotation are provided with every shipment to guarantee traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C (refrigerated) or as specified on the label. Due to its hygroscopic and highly volatile nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) to prevent moisture absorption and decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC/GC)	≥ 99.0% ee
Specific Rotation [α]D20	-15° to -18° (c=1 in CHCl3)
Water Content (Karl Fischer)	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.