Description

(S)-2-Chloropropanoyl Chloride is a chiral, highly reactive acid chloride derivative used as a key building block in asymmetric synthesis. Its value lies in its ability to introduce the (S)-2-chloropropionyl moiety, a crucial intermediate for constructing complex molecules with defined stereochemistry. This compound is essential for research and production in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and chiral agrochemicals.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of enantiomerically pure drugs, including certain antibiotics and cardiovascular agents.
• Agrochemical Synthesis: Used in the production of chiral herbicides, fungicides, and pesticides where specific stereochemistry is required for bioactivity.
• Peptide Chemistry: Serves as a reagent for the introduction of chiral α-chloro acyl groups in peptide modification and drug conjugate synthesis.
• Asymmetric Catalysis Research: Employed as a substrate or precursor in the development and study of new asymmetric catalytic reactions.
• Liquid Crystal & Advanced Material Precursor: Acts as a starting material for synthesizing chiral dopants and other functionalized organic compounds for material science.
• Custom Synthesis & Contract Manufacturing: A vital raw material for fine chemical companies offering bespoke synthesis services for clients in life sciences.

Basic Information

Product Name	(S)-2-Chloropropanoyl Chloride
CAS No.	70110-24-6
Molecular Formula	C3H4Cl2O
Molecular Weight	126.97 g/mol
Synonyms	(S)-(-)-2-Chloropropionyl Chloride; (S)-2-Chloropropionyl Chloride; L-2-Chloropropanoyl Chloride; (S)-α-Chloropropionyl Chloride; (2S)-2-Chloropropanoyl Chloride; (S)-(-)-α-Chloropropionyl Chloride; Propionyl chloride, 2-chloro-, (S)-; (S)-Chloropropanoyl chloride
EINECS	Contact for details

Quality Control

Our (S)-2-Chloropropanoyl Chloride is manufactured under strict quality control protocols to ensure high chemical and enantiomeric purity, meeting the stringent requirements of advanced organic synthesis. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, enantiomeric excess (e.e.), and impurity profile. We adhere to cGMP principles where applicable to support our clients in regulated markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and highly volatile nature, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) at temperatures between 2°C and 8°C for long-term stability. Keep away from strong bases, oxidizing agents, and moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms
Assay (GC/HPLC)	≥ 98.0%
Enantiomeric Excess (e.e.) (Chiral HPLC)	≥ 99.0%
Water Content (Karl Fischer)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.