Description

Adenylyl-(2'-5')-Adenylyl-(2'-5')Adenosine is a defined, high-purity oligoadenylate compound, specifically a trimer of adenosine linked via unique 2'-5' phosphodiester bonds. This molecular structure is of significant interest in biochemical and pharmaceutical research, particularly in the study of innate immune response pathways and RNA metabolism. It serves as a critical reference standard and intermediate for researchers and manufacturers in the fields of immunology, virology, and oligonucleotide therapeutics. The compound's defined sequence and linkage are essential for investigating the mechanisms and biological activities of 2-5A systems.

Application

• Biochemical Research: Used as a reference standard and substrate in studies of the 2-5A synthetase/RNase L antiviral pathway.
• Pharmaceutical Development: Serves as a key intermediate or building block in the synthesis of novel oligonucleotide-based therapeutics and probes.
• Enzymology Studies: Acts as a specific substrate for enzymes that recognize or cleave 2'-5' linked oligoadenylates.
• Cell Signaling Research: Employed to investigate the role of 2-5A in interferon-mediated cellular responses and apoptosis.
• Diagnostic Reagent Manufacturing: Utilized in the production of kits and assays designed to detect components of the interferon response system.
• Academic Research: A vital tool for universities and research institutes exploring innate immunity and RNA biology.

Basic Information

Product Name	Adenylyl-(2'-5')-Adenylyl-(2'-5')Adenosine
CAS No.	70062-83-8
Molecular Formula	C30H37N15O19P2
Molecular Weight	993.66 g/mol
Synonyms	2',5'-Oligoadenylate trimer; 2-5A trimer; ppp(A2'p)2A; 2',5'-Triadenylic acid; Adenosine-2',5'-triadenylic acid; 5'-Triphosphorylated adenyl-(2',5')-adenyl-(2',5')-adenosine; (2'-5')A3; 2',5'-Linked oligoadenylate (n=3)
EINECS	Contact for details

Quality Control

Our Adenylyl-(2'-5')-Adenylyl-(2'-5')Adenosine is produced under stringent conditions to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous internal quality standards to support the integrity of your scientific work. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or light should be avoided to maintain stability and purity. Allow the product to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.