Description

(1-tert-Butylcyclohexyl) Chloroformate is a specialized organic reagent belonging to the chloroformate ester class, widely recognized for its utility as a versatile protecting and activating agent in advanced synthetic chemistry. Its primary value lies in its ability to introduce the bulky, lipophilic tert-butylcyclohexyl moiety, which can be crucial for directing reactions, modifying solubility, or serving as a temporary protecting group for sensitive functionalities. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries engaged in the synthesis of complex molecules, peptides, and novel intermediates where precise molecular manipulation is required.

Application

• Pharmaceutical Intermediate Synthesis: Used as a key reagent for the protection of amines and alcohols during multi-step synthesis of active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Serves as a coupling agent or protecting group in solid-phase and solution-phase peptide synthesis to control regioselectivity.
• Agrochemical Development: Employed in the synthesis of novel herbicide and pesticide intermediates, leveraging its bulky group to influence biological activity.
• Polymer Modification: Acts as a functionalization agent to introduce tert-butylcyclohexyl carbonate groups into polymer chains, altering material properties.
• Chiral Auxiliary and Ligand Preparation: Utilized in the preparation of chiral auxiliaries or ligands for asymmetric catalysis.
• Custom Chemical Synthesis: A critical building block for contract research and manufacturing organizations (CROs/CMOs) producing bespoke fine chemicals.

Basic Information

Product Name	(1-tert-Butylcyclohexyl) Chloroformate
CAS No.	70042-58-9
Molecular Formula	C11H19ClO2
Molecular Weight	218.72 g/mol
Synonyms	1-(1,1-Dimethylethyl)cyclohexyl chloroformate; tert-Butylcyclohexyl chloroformate; Chloroformic acid 1-tert-butylcyclohexyl ester; 1-tert-Butylcyclohexyl carbonochloridate; TBCC; (1-tert-Butylcyclohexyloxy)carbonyl chloride
EINECS	Contact for details

Quality Control

Our (1-tert-Butylcyclohexyl) Chloroformate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and industrial applications. Each lot undergoes comprehensive analytical testing, including assay (by titration or HPLC), identity confirmation (IR, NMR), and impurity profiling. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (Titration)	≥ 97.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.