Description

Terazosin Hydrochloride Dihydrate is a high-purity active pharmaceutical ingredient (API) and a selective α-1 adrenergic receptor antagonist. It is a critical intermediate and final active substance used in the manufacture of antihypertensive and benign prostatic hyperplasia (BPH) medications. This compound is essential for pharmaceutical manufacturers and research institutions developing and producing cardiovascular and urological therapeutics. Consistent quality and reliable supply are paramount for ensuring the efficacy and safety of the final drug products.

Application

• Pharmaceutical API: Primary use as the active ingredient in finished dosage forms for the treatment of hypertension and benign prostatic hyperplasia (BPH).
• Generic Drug Manufacturing: Sourcing for the production of generic versions of α-blocker medications.
• Pharmaceutical Research & Development (R&D): Utilized in preclinical and clinical studies for new drug formulations and combination therapies.
• Reference Standard: Serves as a high-purity chemical reference standard for quality control and analytical method development in laboratories.
• Intermediate Synthesis: Used in the synthetic pathway for creating more complex pharmaceutical compounds.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific drug production.

Basic Information

Product Name	Terazosin Hydrochloride Dihydrate
CAS No.	70024-40-7
Molecular Formula	C₁₉H₂₈ClN₅O₅ • 2H₂O
Molecular Weight	459.93 g/mol (anhydrous basis)
Synonyms	Terazosin HCl Dihydrate; Terazosin Monohydrochloride Dihydrate; (±)-Terazosin Hydrochloride Dihydrate; 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[[(2-tetrahydro-2-furanyl)carbonyl]piperazine Hydrochloride Dihydrate; Hytrin (brand name); Heitrin; Vicard; Terazosina Cloridrato Diidrato; Terazosinum Hydrochloricum Dihydricum
EINECS	Contact for details

Quality Control

Our Terazosin Hydrochloride Dihydrate is manufactured and tested under strict quality management systems. We ensure compliance with current industry standards for pharmaceutical ingredients. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	6.0% - 8.0%
Related Substances (HPLC)	Individual impurity: NMT 0.5% Total impurities: NMT 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	< 20 ppm
Loss on Drying	NMT 1.0% (at 105°C)
Specific Rotation	- Contact for details -

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.