Description

4-Nitrophenyl Chloroformate is a highly reactive and versatile chemical intermediate primarily used for the synthesis of active esters and carbonate derivatives. Its core value lies in its ability to act as an efficient coupling agent for the introduction of the 4-nitrophenoxycarbonyl group, facilitating the formation of amides, esters, and carbamates under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for peptide synthesis, polymer modification, and the development of prodrugs.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), especially for creating carbonate and carbamate prodrugs to enhance drug solubility and bioavailability.
• Peptide Synthesis: Used as a coupling agent for the preparation of peptide bonds and the synthesis of protected amino acid derivatives.
• Polymer Chemistry: Employed in the surface modification of polymers and the synthesis of functional polycarbonates and polyurethanes with specific end-groups.
• Agrochemical Production: Intermediate in the manufacture of certain herbicides, fungicides, and plant growth regulators that contain carbamate functionalities.
• Bioconjugation: Facilitates the labeling and cross-linking of biomolecules (proteins, antibodies) for diagnostic assays and biochemical research.
• Organic Synthesis: A valuable building block for constructing complex organic molecules, including heterocycles and chiral auxiliaries.

Basic Information

Product Name	4-Nitrophenyl Chloroformate
CAS No.	7693-46-1
Molecular Formula	C7H4ClNO4
Molecular Weight	201.56 g/mol
Synonyms	p-Nitrophenyl Chloroformate; 4-Nitrophenyl Carbonochloridate; Chloroformic Acid 4-Nitrophenyl Ester; p-Nitrophenyl Chlorocarbonate; Carbonochloridic Acid 4-Nitrophenyl Ester; NPC; 4-NPC; 4-Nitrophenyloxycarbonyl Chloride
EINECS	231-701-2

Quality Control

Our 4-Nitrophenyl Chloroformate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, alcohols, and water.

Specification

Item	Specification
Appearance	White to pale yellow crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	74 - 78 °C
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.