Description

4-Methoxyphenyl Chloroformate is a versatile and highly reactive chloroformate ester, widely used as a key building block in organic synthesis. Its primary value lies in its role as a protecting group reagent and an intermediate for the synthesis of more complex molecules, particularly in pharmaceutical and agrochemical research. This compound is essential for industries focused on developing active pharmaceutical ingredients (APIs), fine chemicals, and advanced material precursors.

Application

• Pharmaceutical Intermediate: A critical reagent in the synthesis of carbamate prodrugs and for the introduction of the 4-methoxyphenoxycarbonyl protecting group.
• Agrochemical Synthesis: Used in the production of certain herbicides and pesticides where the methoxyphenyl moiety is required.
• Polymer Chemistry: Serves as a monomer or modifying agent in the synthesis of specialized polycarbonates and other functional polymers.
• Peptide Chemistry: Employed for the temporary protection of amine functionalities during solid-phase and solution-phase peptide synthesis.
• Material Science: Acts as a surface modifying agent or a cross-linking component in advanced material formulations.
• Research & Development: A valuable tool in academic and industrial R&D labs for exploring new synthetic methodologies and creating novel chemical entities.

Basic Information

Product Name	4-Methoxyphenyl Chloroformate
CAS No.	7693-41-6
Molecular Formula	C8H7ClO3
Molecular Weight	186.59 g/mol
Synonyms	p-Methoxyphenyl chloroformate; 4-Methoxyphenyl carbonochloridate; 4-Methoxybenzyl chloroformate (common misnomer); p-Anisyl chloroformate; Carbonochloridic acid, 4-methoxyphenyl ester; 4-Methoxybenzenol chloroformate; 1-Methoxy-4-(chlorocarbonyloxy)benzene; (4-Methoxyphenoxy)carbonyl chloride
EINECS	231-704-8

Quality Control

Our 4-Methoxyphenyl Chloroformate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) for every batch, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to meet the stringent requirements of GMP and ISO standards where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Density (at 20°C)	~1.30 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.