Description

Z-Menthyl Chloroformate is a versatile chiral chloroformate ester derived from menthol, serving as a critical reagent for the introduction of the menthyloxycarbonyl (Moc) protecting group. Its primary value lies in enabling stereoselective synthesis and protecting amine functionalities in complex organic molecules, particularly in pharmaceutical intermediates. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity chiral auxiliaries and protecting groups.

Application

• Chiral Auxiliary in Asymmetric Synthesis: Used to create diastereomeric derivatives for the resolution of racemic amines and alcohols.
• Amine Protection in Peptide Synthesis: Acts as a protecting group for amino acids during solid-phase and solution-phase peptide synthesis.
• Intermediate for Pharmaceutical APIs: Key building block in the synthesis of stereochemically pure active pharmaceutical ingredients (APIs).
• Agrochemical Intermediate: Employed in the production of chiral herbicides, fungicides, and insecticides.
• Derivatization Agent for Analysis: Used in chromatography (HPLC, GC) to form stable, separable derivatives of chiral compounds for analytical purposes.
• Material Science Research: Utilized in the synthesis of specialized polymers and liquid crystals where chiral centers are required.

Basic Information

Product Name	Z-Menthyl Chloroformate
CAS No.	7635-53-2
Molecular Formula	C11H19ClO2
Molecular Weight	218.72 g/mol
Synonyms	(-)-Menthyl Chloroformate; L-Menthyl Chloroformate; (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl Chloroformate; Menthyloxycarbonyl Chloride; Moc-Cl; (1R,2S,5R)-Menthyl Chloroformate; Chloroformic Acid Menthyl Ester
EINECS	231-567-1

Quality Control

Our Z-Menthyl Chloroformate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC and GC, to ensure it meets the high standards required for synthetic applications. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at 2-8°C (refrigerated) or as specified on the label. Due to its hygroscopic and moisture-sensitive nature, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC/GC)	≥ 99.0% ee
Water Content (Karl Fischer)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.