Description

α-D-Ribofuranose 5-(Dihydrogen Phosphate) 1-(Trihydrogen Diphosphate) is a high-purity biochemical intermediate, also known as ADP-ribose, which plays a critical role in cellular energy transfer and signaling pathways. This compound is essential for researchers and manufacturers requiring a reliable and consistent source for nucleotide synthesis and metabolic studies. It is primarily utilized in the life sciences sector for applications in enzymology, molecular biology, and the development of pharmaceutical actives.

Application

• Enzyme Substrate & Research: Critical substrate for studying poly(ADP-ribose) polymerases (PARPs), sirtuins, and other ADP-ribosyltransferases involved in DNA repair, gene expression, and cell signaling.
• Nucleotide Synthesis: Serves as a key building block and precursor in the chemical and enzymatic synthesis of specialized nucleotides and their analogs.
• Metabolic Pathway Analysis: Used in biochemical assays to investigate NAD+ metabolism, calcium signaling, and other vital cellular processes.
• Pharmaceutical Development: Employed in the research and development of potential therapeutic agents targeting cancer, neurodegenerative diseases, and inflammation.
• Diagnostic Reagent Manufacturing: A component in the formulation of high-sensitivity assay kits for clinical and research diagnostics.

Basic Information

Product Name	α-D-Ribofuranose 5-(Dihydrogen Phosphate) 1-(Trihydrogen Diphosphate)
CAS No.	7540-64-9
Molecular Formula	C15H23N5O14P2
Molecular Weight	559.32 g/mol
Synonyms	Adenosine 5'-diphosphoribose; ADP-Ribose; ADPR; Adenosine diphosphate ribose; Adenosine 5'-diphospho-5-D-ribofuranose; 5'-O-[(5-O-{[(2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}phosphono)hydroxyphosphoryl]-D-ribofuranose
EINECS	Contact for details

Quality Control

Our α-D-Ribofuranose 5-(Dihydrogen Phosphate) 1-(Trihydrogen Diphosphate) is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for research and production. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 3.0%
Heavy Metals	≤ 10 ppm
Biological Activity (Enzymatic Assay)	Conforms
Endotoxin (LAL)	< 1.0 EU/mg (for applicable grades)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.